Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats

Joint Authors

Zhu, Yudan
Zhang, Shuzhang
Shen, Mei
Zhang, Zhiping
Xu, Kan
Cheng, Jiwei
Ge, Yiqin
Tao, Jie

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-03-18

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Dingxian pill has been used as an antiepilepsy agent in China from ancient to modern times, of which the concrete pharmacological characterization and the underlying molecular mechanism remain unclear.

The present study was undertaken to investigate them by animal behavior, electroencephalogram (EEG), Morris water maze, immunohistochemistry, transcriptomics, and real-time PCR.

In our results, the treatment of Dingxian pill dose-dependently inhibited PTZ-induced seizure-like behavior and reduced the seizure grades, LFP power spectral density, and brain wave of the epileptiform EEG component induced by PTZ.

In Morris water maze tests, the learning and memory ability of kindled epileptic rats could be attenuated more efficiently by Dingxian pill.

For the immediate early gene c-fos, the expression was reduced after Dingxian pill treatment, and the difference was significant between the treatment and the model group.

Through the transcriptome analysis of the gene expression in hippocampus, Egr3, Nrg, Arc, and Ptgs2, closely related to epilepsy, had been proved to be downregulated by application of Dingxian pill.

All of the results not only highlight the antiepileptic effects of Dingxian pill and its molecular mechanism, but also provide a modern validity theory for the clinical application of traditional Chinese medicine (TCM).

American Psychological Association (APA)

Zhu, Yudan& Zhang, Shuzhang& Shen, Mei& Zhang, Zhiping& Xu, Kan& Cheng, Jiwei…[et al.]. 2019. Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149809

Modern Language Association (MLA)

Zhu, Yudan…[et al.]. Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1149809

American Medical Association (AMA)

Zhu, Yudan& Zhang, Shuzhang& Shen, Mei& Zhang, Zhiping& Xu, Kan& Cheng, Jiwei…[et al.]. Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149809

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1149809