Effects of Alismatis Rhizoma and Rhizoma Smilacis Glabrae Decoction on Hyperuricemia in Rats
Joint Authors
Cheng, Shupin
Sun, Hanxiao
Li, Xiaomeng
Yan, Jiuming
Peng, Zihao
You, Yiping
Zhang, Lishi
Chen, Jinyao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The combination of Alismatis Rhizoma (AR) and Rhizoma Smilacis Glabrae (RSG), as Chinese herb medicine, has been used for their uric acid-lowering effect.
However, the effects and mechanism of the combination of the two medicines have not been fully reported.
Therefore, to explore the effects of AR-RSG combination decoction on the treatment of chronic hyperuricemia (HUA) in rats as well as the underlying mechanisms, in this study, at the first stage, a long-term HUA rats model was established by gavage of oteracil potassium plus adenine; allopurinol was used as the positive control, and the uric acid-lowering effects of AR or RSG decoction alone with low and high dose were evaluated, respectively.
Serum uric acid (UA) and xanthine oxidase (XOD) were determined mainly, and pathological analysis of the kidney and liver was carried out after sacrifice of the animals.
And then, at the second stage, four dose groups of AR-RSG combination treatment were investigated in HUA rats.
In addition to the indicators measured at the first stage, the expression of urate anion exchanger 1 (URAT1) in rat kidney was determined by immunohistochemistry.
We discovered that the UA levels of the model group in both stages were significantly and steadily higher than those of control groups.
AR and RSG alone or in combination possess ability to decrease serum UA level of HUA rats, with effects more marked in the combination groups.
The uric acid-lowering mechanism of AR-RSG combination may be related to its inhibiting activity of XOD, improving kidney damage and downregulating the expression of URAT1 in kidney.
American Psychological Association (APA)
Cheng, Shupin& Sun, Hanxiao& Li, Xiaomeng& Yan, Jiuming& Peng, Zihao& You, Yiping…[et al.]. 2019. Effects of Alismatis Rhizoma and Rhizoma Smilacis Glabrae Decoction on Hyperuricemia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149827
Modern Language Association (MLA)
Cheng, Shupin…[et al.]. Effects of Alismatis Rhizoma and Rhizoma Smilacis Glabrae Decoction on Hyperuricemia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1149827
American Medical Association (AMA)
Cheng, Shupin& Sun, Hanxiao& Li, Xiaomeng& Yan, Jiuming& Peng, Zihao& You, Yiping…[et al.]. Effects of Alismatis Rhizoma and Rhizoma Smilacis Glabrae Decoction on Hyperuricemia in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149827