A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman’s Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment
Joint Authors
Tincani, Angela
Morello, E.
Cartella, S.
Bonzanini, O.
Filippini, Matteo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
A 38-year-old woman was referred to our hospital for rheumatologic manifestations (migrant arthritis and tenosynovitis), without psoriasis or family history of psoriasis, gastroenteric manifestations, or recent genitourinary infections.
The instrumental and laboratory tests have suggested a diagnosis of undifferentiated seronegative HLA-B27-positive spondyloarthritis with predominantly peripheral involvement.
The symptoms were very severe and resistant to anti-inflammatory drugs and steroids.
She had a history of hyaline-vascular unicentric Castleman’s disease (HBV, HIV, and HHV-8 negative) treated with surgery resection.
After a first pharmacological attempt with sulfasalazine (suspended for urticarial rash), we managed the patient with monotherapy tocilizumab 8 mg/kg, with full response of rheumatologic manifestations.
The efficacy of tocilizumab was confirmed even after a follow-up of three years.
Our experience seems to describe a new late-onset autoimmune disease (only 21 cases described in literature) potentially related to Castleman’s disease.
The patient experienced marked improvement from IL-6-based therapy (tocilizumab).
American Psychological Association (APA)
Filippini, Matteo& Cartella, S.& Bonzanini, O.& Morello, E.& Tincani, Angela. 2018. A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman’s Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment. Case Reports in Rheumatology،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1149830
Modern Language Association (MLA)
Filippini, Matteo…[et al.]. A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman’s Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment. Case Reports in Rheumatology No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1149830
American Medical Association (AMA)
Filippini, Matteo& Cartella, S.& Bonzanini, O.& Morello, E.& Tincani, Angela. A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman’s Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment. Case Reports in Rheumatology. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1149830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149830