GCMS-Based Metabolomics Approach to Evaluate the Effect of Jackyakgamcho-Tang on Acute Colitis
Joint Authors
Seo, Chang-Seob
Na, Changsu
Youn, Daehwan
Seo, Seung-Ho
Park, Seong-Eun
Kim, Eun-Ju
Lee, Yu-Mi
Lee, Soon-Young
Bok, So-Hyeon
Park, Dae-Hun
Byun, Sung-Hoon
Jun, Ki Young
Kim, Dae Sung
Son, Hong-Seok
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of this study was to examine the effects of Jackyakgamcho-tang (JGT) on acute colitis.
GC/MS-based metabolomics and NGS-based metagenomics were applied to investigate the alteration of metabolites and microbiota in an acute colitis model.
The severity of acute colitis symptoms was alleviated by JGT treatment.
Induction of colitis and JGT treatment changed compositions of gut microbiota and inflammatory cytokine levels (TNF-α and IL-6).
They also substantially change metabolites (i.e., lactic acid, linoleic acid, monostearin, and palmitoylglycerol).
In addition, some clear correlations were observed among metabolites, cytokine, and microbiota.
This study highlights the applicability of metabolomics and metagenomics study for evaluating anti-inflammatory effects of a new functional herbal medicine as a therapeutic agent for acute colitis.
American Psychological Association (APA)
Seo, Seung-Ho& Park, Seong-Eun& Kim, Eun-Ju& Youn, Daehwan& Lee, Yu-Mi& Lee, Soon-Young…[et al.]. 2019. GCMS-Based Metabolomics Approach to Evaluate the Effect of Jackyakgamcho-Tang on Acute Colitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149838
Modern Language Association (MLA)
Seo, Seung-Ho…[et al.]. GCMS-Based Metabolomics Approach to Evaluate the Effect of Jackyakgamcho-Tang on Acute Colitis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1149838
American Medical Association (AMA)
Seo, Seung-Ho& Park, Seong-Eun& Kim, Eun-Ju& Youn, Daehwan& Lee, Yu-Mi& Lee, Soon-Young…[et al.]. GCMS-Based Metabolomics Approach to Evaluate the Effect of Jackyakgamcho-Tang on Acute Colitis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149838