Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction
Joint Authors
Gerdprasert, Orapin
Choomchuay, Nantana
Chantong, Boonrat
Sutanthavibul, Narueporn
Meksuriyen, Duangdeun
Nusuetrong, Punnee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Phikud Navakot (PN) is nine major herbs in a famous traditional Thai recipe namely “Yahom Navakot” used to treat cardiovascular disorders.
This study investigated the cardioprotective effects of PN formula on isoproterenol-induced myocardial infarction (IMI) in Sprague-Dawley rats.
Forty-five rats were randomly divided into nine groups (n = 5 per group): the control, the IMI, the IMI + propranolol, the control or the IMI + PN formula (PN ethanolic extract at doses of 64, 127, or 255 mg/kg) by oroesophageal gavage for 28 days.
The ST segment and serum troponin T levels were significantly increased in IMI rats.
PN did not eliminate tissue necrosis, infiltration of inflammatory cells, or interstitial edema in IMI rats.
All doses of PN decreased (p<0.001) serum TNF-α and IL-6 levels.
PN (127 and 255 mg/kg) up-regulated (p<0.05) heme oxygenase (HO)-1 expression, whereas PN (255 mg/kg) significantly increased superoxide dismutase (SOD) 1 and 2 expression, compared with IMI rats.
Nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 expression significantly increased in IMI rats and IMI rats that received PN.
PN formula possesses potential anti-inflammatory and antioxidant properties by modulating the levels of TNF-α, IL-6 and antioxidant enzymes.
Our study reveals a novel cardioprotective effect of PN in IMI rats through the Nrf2/HO-1 signaling.
American Psychological Association (APA)
Gerdprasert, Orapin& Choomchuay, Nantana& Chantong, Boonrat& Sutanthavibul, Narueporn& Meksuriyen, Duangdeun& Nusuetrong, Punnee. 2019. Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1149916
Modern Language Association (MLA)
Gerdprasert, Orapin…[et al.]. Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1149916
American Medical Association (AMA)
Gerdprasert, Orapin& Choomchuay, Nantana& Chantong, Boonrat& Sutanthavibul, Narueporn& Meksuriyen, Duangdeun& Nusuetrong, Punnee. Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1149916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149916