Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature
Joint Authors
Majjad, A.
Bezza, A.
Biyi, A.
El Ochi, M. R.
El Maghraoui, Abdellah
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Antitumor necrosis factor therapies have revolutionized the treatment of some inflammatory diseases.
However, the use of these agents is associated with the development of many paradoxical autoimmune diseases.
Less well-recognized is the association with sarcoidosis.
We report a 55-year-old female with long-standing ankylosing spondylitis who developed persistent dry cough and dyspnea while receiving etanercept therapy.
High-resolution computed tomography scanning showed mediastinal lymphadenopathy and multiple nodules in both lung fields developed two months after the administration of etanercept.
Lymph node biopsy was not practicable.
Histopathological examination of minor salivary gland biopsy revealed noncaseating granulomata, and the serum angiotensin-converting enzyme was very elevated.
All infectious studies were negative.
Etanercept was discontinued plus a course of corticosteroids with a clinical improvement, and a follow-up high-resolution computed tomography scanning 4 months later showed evident regression of mediastinal lymph nodes and pulmonary nodules.
Potential pathogenic mechanisms of this paradoxical effect of tumor necrosis factor-alpha blocking agents are discussed.
American Psychological Association (APA)
Majjad, A.& Bezza, A.& Biyi, A.& El Ochi, M. R.& El Maghraoui, Abdellah. 2018. Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature. Case Reports in Rheumatology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1149929
Modern Language Association (MLA)
Majjad, A.…[et al.]. Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature. Case Reports in Rheumatology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1149929
American Medical Association (AMA)
Majjad, A.& Bezza, A.& Biyi, A.& El Ochi, M. R.& El Maghraoui, Abdellah. Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature. Case Reports in Rheumatology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1149929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149929