Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review
Joint Authors
Kishida, Dai
Ogawa, Yuka
Shimojima, Yasuhiro
Hayashi, Koichi
Sekijima, Yoshiki
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We describe the case of a 48-year-old man with dermatomyositis (DM) who demonstrated rapidly progressive interstitial lung disease (RP-ILD) and refractory cutaneous involvement together with high levels of anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab).
Even after combination immunosuppressive therapy including a corticosteroid, cyclosporine A, and intravenous cyclophosphamide, his respiratory insufficiency and cutaneous involvement progressively worsened.
However, the administration of rituximab (RTX) resulted in clinical remission as well as a visible reduction in anti-MDA5-Ab levels, suggesting that RTX could be a useful remedy in cases refractory to conventional immunosuppressive agents, especially those of RP-ILD related to anti-MDA5-Ab–positive DM.
American Psychological Association (APA)
Ogawa, Yuka& Kishida, Dai& Shimojima, Yasuhiro& Hayashi, Koichi& Sekijima, Yoshiki. 2017. Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review. Case Reports in Rheumatology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1149970
Modern Language Association (MLA)
Ogawa, Yuka…[et al.]. Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review. Case Reports in Rheumatology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1149970
American Medical Association (AMA)
Ogawa, Yuka& Kishida, Dai& Shimojima, Yasuhiro& Hayashi, Koichi& Sekijima, Yoshiki. Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review. Case Reports in Rheumatology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1149970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149970
