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Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract
Joint Authors
Yi, Young-Su
Park, Sang Hee
Kim, Mi-Yeon
Cho, Jae Youl
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Despite a large number of studies reporting a variety of biological and pharmacological activities of Momordica charantia, its skin protective properties are poorly understood.
The present study aimed to explore the skin protective properties of Momordica charantia methanol extract (Mc-ME) and the underlying mechanism in keratinocytes, fibroblasts, and melanocytes.
Mc-ME exhibited an antioxidative property by decreasing radical levels in HaCaT keratinocytes and a cytoprotective property in H2O2-damaged HaCaT cells, which was mediated by increasing the expression or activation of Kelch-like ECH-associated protein 1 (KEAP1), HO-1, p85/PI3K, and AKT.
Mc-ME was also active against wrinkle formation by regulating the activity or expression of tissue remodeling factors such as elastase, type 1 collagen, and matrix metalloproteinase (MMP)-1 and -9 and tissue-protecting enzymes such as hemeoxygenase-1 (HO-1) and sirtuin 1 (SIRT1) in NIH3T3 fibroblasts and HaCaT cells, in addition to increasing the proliferation of HaCaT cells.
Mc-ME also showed antidehydration properties by inducing the expression of natural moisturizing factors such as filaggrin (FLG), transglutaminase-1 (TGM-1), and hyaluronic acid synthase (HAS)-1, -2, and -3 in HaCaT cells.
Moreover, Mc-ME showed an antimelanogenic property by inhibiting the synthesis and secretion of melanin from B16F10 melanoma cells via suppression of tyrosinase activity.
Taken together, these results suggest that Mc-ME plays a skin protective role through its antioxidative, cytoprotective, skin remodeling, moisturizing, and antimelanogenic properties and might be a new and promising skin protective cosmeceutical.
American Psychological Association (APA)
Park, Sang Hee& Yi, Young-Su& Kim, Mi-Yeon& Cho, Jae Youl. 2019. Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1150000
Modern Language Association (MLA)
Park, Sang Hee…[et al.]. Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1150000
American Medical Association (AMA)
Park, Sang Hee& Yi, Young-Su& Kim, Mi-Yeon& Cho, Jae Youl. Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1150000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150000