Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines
Joint Authors
Farias, Kleber Juvenal Silva
Bernardes-Oliveira, Emanuelly
Gomes, Dayanne Lopes
Fernandes-Pedrosa, Matheus de Freitas
Crispim, Janaina Cristiana de Oliveira
Araújo, Josélio Maria Galvão de
Silva, Wilmar Dias da
Rocha, Hugo Alexandre Oliveira
Donadi, Eduardo Antônio
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cervical cancer (CC) is classified as the fourth most common type of cancer in women worldwide and remains a serious public health problem in many underdeveloped countries.
Human papillomavirus (HPV), mainly types 16 and 18, has been established as a precursory etiologic agent for this type of cancer.
Several therapeutic attempts have been studied and applied, aiming at its control.
However, not only do classical treatments such as chemotherapies and radiotherapies target tumor cells, but also they cause damage to several healthy cells.
For these reasons, the search for new biologically active chemotherapeutic components is of great importance.
In this study, we investigated the effect of Tityus serrulatus scorpion venom (TsV) on CC lines.
There are very few studies exploring venom of scorpions, and, to our knowledge, no study has been conducted using the venom of the scorpion TsV for treatment of cervical cancer lines.
After challenge with TsV, the MTT assay demonstrated cytotoxic effect on HeLa line.
Similarly, the cell death process in HeLa analyzed by flow cytometry suggests death via caspase, since the pan-caspase inhibitor z-VAD-fmk significantly reduced the apoptotic response to the treatment.
These results suggest that venom of TsV can be a potential source for the isolation of effective antiproliferative and apoptotic molecules in the treatment of CC.
American Psychological Association (APA)
Bernardes-Oliveira, Emanuelly& Farias, Kleber Juvenal Silva& Gomes, Dayanne Lopes& Araújo, Josélio Maria Galvão de& Silva, Wilmar Dias da& Rocha, Hugo Alexandre Oliveira…[et al.]. 2019. Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1150014
Modern Language Association (MLA)
Bernardes-Oliveira, Emanuelly…[et al.]. Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1150014
American Medical Association (AMA)
Bernardes-Oliveira, Emanuelly& Farias, Kleber Juvenal Silva& Gomes, Dayanne Lopes& Araújo, Josélio Maria Galvão de& Silva, Wilmar Dias da& Rocha, Hugo Alexandre Oliveira…[et al.]. Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1150014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150014