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Chinese Herbal Medicines Compared with N-Acetylcysteine for the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review of Randomized Controlled Trials
Joint Authors
Guo, Taipin
Guo, Jing
Li, Bin
Wu, Wenbin
Wang, Zhichao
Wang, Fei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-13
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Background.
Idiopathic pulmonary fibrosis (IPF) is a major global health problem.
The prevalence of the disease appears to be increasing.
There is no curative therapy for IPF except lung transplantation.
Chinese herbal medicines (CHMs) are showing promise for treatment of IPF.
However, their effectiveness and safety are still unclear and deserve further investigation.
The aim of this systematic review is to access the efficacy and safety of CHMs in treating IPF.
Methods.
The protocol of this review is registered at PROSPERO.
We searched seven main databases for randomized clinical trials (RCTs) on CHMs for IPF from their inception to June 4, 2018.
The methodological quality of RCTs was assessed using the Cochrane risk of bias tool.
All trials included were analyzed according to the criteria of the Cochrane Handbook.
Review Manager 5.3, R-3.5.2 software, and Grade pro GDT web solution were used for data synthesis and analysis.
Results.
Thirteen randomized clinical trials enrolling 733 patients were included.
All trials included had clear outcome indicators.
The methodological quality of included trials was generally “poor.” Few trials reported methods of randomization.
One trial on Xuefu-zhuyu capsule assessed rate of acute exacerbation and mortality after treatment for 72 weeks and found no statistically significant difference between two groups.
This meta-analysis demonstrated a significant improvement in QOL of IPF patients when CHMs was applied or combined with conventional medicine treatment.
6MWT was significantly improved in IPF patients after using CHMs or combined with conventional medicine treatment.
CHMs treatment also had a certain improvement in TLC and DLCO, but the effect on FVC was not significant.
Besides, CHMs failed to provide benefits in terms of PaO2.
The reported adverse events were not obvious and severe.
Conclusions.
Some CHMs seem effective and safe as alternative remedies for patients with IPF, suggesting that further study of CHMs in the treatment of IPF is warranted.
Although this systematic review suggests that CHMs may have positive effect on quality of life, 6-minute walk test distance, and lung function (TLC, DLOC%) and seem to be relatively safe during the course of treatment, the results must be treated with great caution because of the methodological flaws of the included trials.
Long-term and high-quality trials are needed in the future to provide clear evidence for the use of CHMs.
American Psychological Association (APA)
Guo, Jing& Li, Bin& Wu, Wenbin& Wang, Zhichao& Wang, Fei& Guo, Taipin. 2019. Chinese Herbal Medicines Compared with N-Acetylcysteine for the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1150031
Modern Language Association (MLA)
Guo, Jing…[et al.]. Chinese Herbal Medicines Compared with N-Acetylcysteine for the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1150031
American Medical Association (AMA)
Guo, Jing& Li, Bin& Wu, Wenbin& Wang, Zhichao& Wang, Fei& Guo, Taipin. Chinese Herbal Medicines Compared with N-Acetylcysteine for the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1150031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150031