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Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines
Joint Authors
Park, Bong-Soo
Kim, In-Ryoung
Yu, Su-Bin
Kang, Hae-Mi
Park, Dan-Bi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cudraxanthone D (CD), derived from the root bark of Cudrania tricuspidata, is a natural xanthone compound.
However, the biological activity of CD in terms of human metabolism has been barely reported to date.
Autophagy is known as a self-degradation process related to cancer cell viability and metastasis.
Herein, we investigated the effects of CD on human oral squamous cell carcinoma (OSCC) metastatic related cell phenotype.
We confirmed that CD effectively decreased proliferation and viability in a time- and dose-dependent manner in human OSCC cells.
In addition, OSCC cell migration, invasion, and EMT were inhibited by CD.
To further determine the underlying mechanism of CD’s inhibition of cell metastatic potential, we established the relationship between EMT and autophagy in OSCC cells.
Thus, our findings indicated that CD inhibited the potential metastatic abilities of OSCC cells by attenuating autophagy.
American Psychological Association (APA)
Yu, Su-Bin& Kang, Hae-Mi& Park, Dan-Bi& Park, Bong-Soo& Kim, In-Ryoung. 2019. Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150047
Modern Language Association (MLA)
Yu, Su-Bin…[et al.]. Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1150047
American Medical Association (AMA)
Yu, Su-Bin& Kang, Hae-Mi& Park, Dan-Bi& Park, Bong-Soo& Kim, In-Ryoung. Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150047