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Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?
Joint Authors
Liu, Dianna
Chen, Feng
Yu, Xue
Xiu, Linlin
Liu, Haiyan
Chen, Shaohong
Gao, Jie
Zhang, Chen
Li, Na
He, Cheng
Zhong, Gansheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sargassum species combined with Glycyrrhiza uralensis is a famous herbal pair in traditional Chinese medicine, as one of the so-called “eighteen antagonistic medicaments.” In the Chinese Pharmacopoeia, two different species of Sargassum, Sargassum pallidum and Sargassum fusiforme, are recorded but they are not clearly differentiated in clinical use.
In this study, we aimed to determine whether the two species of Sargassum could result in different effects when combined with G.
uralensis in Haizao Yuhu Decoction (HYD), which is used for treating thyroid-related diseases, especially goiter.
HYD containing S.
pallidum or S.
fusiforme was administered to rats with propylthiouracil-induced goiter.
After 4 weeks, pathological changes in the thyroid tissue and the relative thyroid weight indicated that HYD containing S.
pallidum or S.
fusiforme protected thyroid tissues from propylthiouracil damage.
Neither species increased the propylthiouracil-induced decrease in serum levels of thyroid hormones.
However, there were some differences in their actions, and only HYD containing S.
fusiforme abated the propylthiouracil-induced elevation of serum thyroid-stimulating hormone levels and activated thyroglobulin mRNA expression.
American Psychological Association (APA)
Liu, Dianna& Chen, Feng& Yu, Xue& Xiu, Linlin& Liu, Haiyan& Chen, Shaohong…[et al.]. 2019. Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1150181
Modern Language Association (MLA)
Liu, Dianna…[et al.]. Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1150181
American Medical Association (AMA)
Liu, Dianna& Chen, Feng& Yu, Xue& Xiu, Linlin& Liu, Haiyan& Chen, Shaohong…[et al.]. Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1150181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150181