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Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3KAktmTOR-Mediated Nrf2HO-1 Pathway
Joint Authors
Xuan, Hongzhuan
Yuan, Wenwen
Chang, Huasong
Liu, Xinying
Wang, Shiqiang
Liu, Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Propolis has been widely used as a dietary supplement for its health benefits, including cardiovascular protective effects.
The aim of this study was to investigate the cytoprotective effects of Brazilian green propolis (BP) against oxidized low-density lipoprotein (Ox-LDL) induced human umbilical vein endothelial cells (HUVECs) damage.
Our results suggested that treatment with BP rescued Ox-LDL-stimulated HUVECs cell viability losses, which might be associated with its inhibitive effects on the cell apoptosis and autophagy.
We also noticed that BP restored Ox-LDL-stimulated HUVECs oxidative stress, by induced antioxidant gene expressions, including Heme oxygenase-1 and its upstream mediator, Nrf2, which were mediated by the activation of the phosphorylation of PI3K/Akt/mTOR.
Pretreatment with wortmannin, PI3K/AKT inhibitor, abolished BP induced Nrf2 nuclear translocation and HO-1 level.
Our results demonstrated that BP protected HUVECs against oxidative damage partly via PI3K/Akt/mTOR-mediated Nrf/HO-1 pathway, which might be applied into preventing Ox-LDL mediated cardiovascular diseases.
American Psychological Association (APA)
Yuan, Wenwen& Chang, Huasong& Liu, Xinying& Wang, Shiqiang& Liu, Hui& Xuan, Hongzhuan. 2019. Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3KAktmTOR-Mediated Nrf2HO-1 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1150225
Modern Language Association (MLA)
Yuan, Wenwen…[et al.]. Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3KAktmTOR-Mediated Nrf2HO-1 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1150225
American Medical Association (AMA)
Yuan, Wenwen& Chang, Huasong& Liu, Xinying& Wang, Shiqiang& Liu, Hui& Xuan, Hongzhuan. Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3KAktmTOR-Mediated Nrf2HO-1 Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1150225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150225