Screening and Identification of Molecular Targets Involved in Preventing Gastric Precancerous Lesions in Chronic Atrophic Gastritis by Qilianshupi Decoction
Joint Authors
Zhang, Yameng
Li, Chao
Sun, Shanmei
Cao, Zhiqun
Chen, Jian
Xiang, Hongjie
Song, Lucheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic atrophic gastritis (CAG) is a common and possibly precancerous digestive tract disease.
Development of drugs with effect of preventing precancerous lesions draws the eyes of global researchers.
Qilianshupi decoction (QLSP) is a Traditional Chinese Medicine (TCM) that is commonly used to treat CAG, but few studies have explored the mechanism of QLSP on treating CAG.
This study investigated the molecular targets of the component herbs of QLSP in preventing precancerous lesions based on network pharmacology.
Network pharmacology analysis revealed that the 6 herbs regulated multiple CAG-related genes, among which the most important were cancer-related pathway (apoptosis, p53, and VEGF) and epithelial cell signaling in Helicobacter pylori infection.
Further animal experiments showed that the expression of survivin and p53 in precancerous lesions of CAG rats was significantly increased which was suppressed by QLSP.
Moreover, telomerase activity was inhibited in precancerous lesions of CAG rats, and telomere length of gastric mucosa was increased, which was reversed by QLSP.
Our results suggest that the components of QLSP prevents gastric precancerous lesions through decreasing the expression of survivin and p53 and regulating telomerase activity and telomere length in CAG.
American Psychological Association (APA)
Zhang, Yameng& Li, Chao& Sun, Shanmei& Cao, Zhiqun& Chen, Jian& Xiang, Hongjie…[et al.]. 2019. Screening and Identification of Molecular Targets Involved in Preventing Gastric Precancerous Lesions in Chronic Atrophic Gastritis by Qilianshupi Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1150240
Modern Language Association (MLA)
Zhang, Yameng…[et al.]. Screening and Identification of Molecular Targets Involved in Preventing Gastric Precancerous Lesions in Chronic Atrophic Gastritis by Qilianshupi Decoction. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1150240
American Medical Association (AMA)
Zhang, Yameng& Li, Chao& Sun, Shanmei& Cao, Zhiqun& Chen, Jian& Xiang, Hongjie…[et al.]. Screening and Identification of Molecular Targets Involved in Preventing Gastric Precancerous Lesions in Chronic Atrophic Gastritis by Qilianshupi Decoction. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1150240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150240