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The Effects of Safflower Yellow on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Clinical Trial
Joint Authors
Zuo, Yun-Xia
Liao, Xue-Lian
Kang, Yan
Li, Xiao-jin
Liu, Jin
Ou, Xiao Feng
Wang, Ru-rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objectives.
To evaluate the efficacy of safflower yellow in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods.
In a prospective, randomized, controlled trial, 127 patients who met the inclusion criteria were enrolled and were randomly divided into two groups.
The control group included 64 patients treated according to the global strategy for diagnosis, management, and prevention of COPD (www.goldcopd.org, updated 2011).
The intervention group included 63 patients who received intravenous infusions of safflower yellow (100 mg of safflower yellow dissolved in 250 ml 0.9% saline) once daily for 14 consecutive days in addition to standard diagnosis and treatment.
The difference in the average length of the hospital stay between the two groups of patients was determined.
The follow-up period was 28 days; the differences in symptoms, clinical indicators, and 28-day mortality in the two groups were compared.
Statistical analysis was conducted using SPSS 22.0 software to determine whether there were statistically significant differences (P <0.05) between groups.
Results.
There were no statistically significant differences between the intervention group and the control group in changes in secondary indicators.
There were no statistically significant differences in the 28-day mortality or in the survival curves of the two groups (P=0.496 and P=0.075, respectively).
Safflower yellow treatment of AECOPD may relieve the patient’s clinical symptoms, such as dyspnoea, shorten the average length of hospital stay (P=0.006, respectively), and decrease the duration of mechanical ventilation.
Conclusion.
Safflower yellow in the treatment of AECOPD has a degree of clinical value.
This trial is registered under the identifier ChiCTR-IPR-17014176.
American Psychological Association (APA)
Li, Xiao-jin& Kang, Yan& Wang, Ru-rong& Liao, Xue-Lian& Ou, Xiao Feng& Liu, Jin…[et al.]. 2019. The Effects of Safflower Yellow on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1150299
Modern Language Association (MLA)
Li, Xiao-jin…[et al.]. The Effects of Safflower Yellow on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1150299
American Medical Association (AMA)
Li, Xiao-jin& Kang, Yan& Wang, Ru-rong& Liao, Xue-Lian& Ou, Xiao Feng& Liu, Jin…[et al.]. The Effects of Safflower Yellow on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1150299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150299