Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of Persea americana and Their Effectiveness in Type 2 Diabetic Rats
Joint Authors
Kouamé, N’Goran M.
Koffi, Camille
N’Zoué, Kanga S.
Yao, N’Guessan A. R.
Doukouré, Brahima
Kamagaté, Mamadou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Native to Mexico, Persea americana Mill.
(avocado) is a fruit tree whose different parts (leaf, bark, roots, and stone) are used in traditional medicine especially against diabetes mellitus.
The aim of this study was to investigate the beneficial effects of 28-day treatment with aqueous, ethanolic, and methanolic leaf extracts on glucose homeostasis in type 2 diabetic mellitus using Wistar rats.
Type 2 diabetes was induced with nicotinamide (120 mg/kg, i.p.) and streptozotocin (65 mg/kg, i.p.).
After 28 days of treatment, histopathological examination of the pancreas, kidneys, liver, and muscle (tibialis anterior) were realized.
Biochemical markers were determined and an intestinal absorption test of D-glucose was performed.
All extracts (100 mg/kg/day, p.o.) significantly (p<0.001) reduced blood glucose level at the 28th day of treatment with a more pronounced effect for methanolic extract.
The treatments were well tolerated and induced a restoration of T-CHOL and HDL-C levels compared to the control group.
Methanolic extract reduced the AIP (atherogenic index of plasma) by 45%.
Histopathological analyzes of the pancreas showed regeneration of islets of Langerhans.
Methanolic extract was the most effective in preventing intestinal glucose uptake up to 60.90% in relation to metformin.
These results justify the use of this plant in traditional medicine against type 2 diabetes.
However, other complementary studies should be done to identify the molecules responsible for this activity and their signaling voice.
American Psychological Association (APA)
Kouamé, N’Goran M.& Koffi, Camille& N’Zoué, Kanga S.& Yao, N’Guessan A. R.& Doukouré, Brahima& Kamagaté, Mamadou. 2019. Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of Persea americana and Their Effectiveness in Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1150316
Modern Language Association (MLA)
Kouamé, N’Goran M.…[et al.]. Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of Persea americana and Their Effectiveness in Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1150316
American Medical Association (AMA)
Kouamé, N’Goran M.& Koffi, Camille& N’Zoué, Kanga S.& Yao, N’Guessan A. R.& Doukouré, Brahima& Kamagaté, Mamadou. Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of Persea americana and Their Effectiveness in Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1150316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150316