Acquired Hemophilia A Presenting as Massive Postoperative Bleeding in a Patient with Oral Squamous Cell Carcinoma
Joint Authors
Kogashiwa, Yasunao
Sugasawa, Masashi
Oba, Susumu
Nakahira, Mitsuhiko
Ebihara, Yasuhiro
Source
Case Reports in Otolaryngology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Acquired hemophilia A (AHA) is an extremely rare and serious bleeding disorder caused by autoantibodies against coagulation factor VIII (FVIII).
Approximately, 10% of patients with AHA have an underlying malignancy.
We report on a 46-year-old man with AHA and advanced oral cancer who presented with massive bleeding after surgery.
Preoperative blood coagulation tests showed no abnormalities.
He underwent radical tumor resection followed by reconstruction using a free rectus abdominal musculocutaneous flap.
Massive subcutaneous hemorrhage developed in his neck and abdomen on the first postoperative day.
The hemorrhage remained uncontrolled, despite embolization of the responsible vessels.
Subsequent laboratory data showed prolonged activated partial thromboplastin time and decreased FVIII levels.
On the basis of his clinical course and the presence of the FVIII inhibitor, we speculated that the patient suffered from AHA.
We administered recombinant activated factor VII and prednisolone, after which the spontaneous bleeding stopped and the subcutaneous hemorrhage resolved.
A review of the literature identified only three previous documented cases of AHA associated with head and neck cancer.
This case indicates that AHA should not be ruled out in patients with uncontrolled postoperative bleeding, while attempting to ensure bleeding control and preventing potentially catastrophic fatal consequences.
American Psychological Association (APA)
Oba, Susumu& Nakahira, Mitsuhiko& Kogashiwa, Yasunao& Ebihara, Yasuhiro& Sugasawa, Masashi. 2020. Acquired Hemophilia A Presenting as Massive Postoperative Bleeding in a Patient with Oral Squamous Cell Carcinoma. Case Reports in Otolaryngology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1150337
Modern Language Association (MLA)
Oba, Susumu…[et al.]. Acquired Hemophilia A Presenting as Massive Postoperative Bleeding in a Patient with Oral Squamous Cell Carcinoma. Case Reports in Otolaryngology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1150337
American Medical Association (AMA)
Oba, Susumu& Nakahira, Mitsuhiko& Kogashiwa, Yasunao& Ebihara, Yasuhiro& Sugasawa, Masashi. Acquired Hemophilia A Presenting as Massive Postoperative Bleeding in a Patient with Oral Squamous Cell Carcinoma. Case Reports in Otolaryngology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1150337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150337