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Protective Effect of Zizyphus lotus L. (Desf.) Fruit against CCl4-Induced Acute Liver Injury in Rat
Joint Authors
Bencheikh, Noureddine
Bouhrim, Mohamed
Kharchoufa, Loubna
Choukri, Mohammed
Bnouham, Mohamed
Elachouri, Mostafa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In Morocco, “Zizyphus lotus L.” is one of the most widely and traditionally used plant species to treat various diseases, including liver disorders.
The present study was conducted to evaluate the aqueous extract of Zizyphus lotus L.
fruit against carbon tetrachloride- (CCL4-) induced liver damage in Wistar rats.
The animals were daily treated with the aqueous extract of Zizyphus lotus L.
fruit using two doses separately 200 and 400 mg/kg body weight for 14 days.
CCL4 was injected intraperitoneally (1 ml/kg body weight) at two times, 7th and 14th days.
At the end of the treatment, rats were sacrificed, and the blood was collected for the assessment of biochemical parameters.
Moreover, the body weight as well as liver weight was determined.
The injection of CCl4 to the rats induced various alterations such as the increase of relative liver weight, serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, triglycerides, very low-density lipoproteins, total cholesterol (slight increase), creatinine, urea, uric acid, and malondialdehyde.
On the contrary, the effects of CCL4 lead to the reduction in serum levels of high-density lipoprotein.
However, the daily administration of the aqueous extract of Zizyphus lotus L.
fruit to the injected rats with CCL4 restored this abnormal variation in these biochemical parameters to normal values.
Based on the results obtained in this study, it seems that the aqueous extract of Zizyphus lotus L.
fruit has an hepatoprotective effect against hepatic lesions induced by CCL4 in rats.
American Psychological Association (APA)
Bencheikh, Noureddine& Bouhrim, Mohamed& Kharchoufa, Loubna& Choukri, Mohammed& Bnouham, Mohamed& Elachouri, Mostafa. 2019. Protective Effect of Zizyphus lotus L. (Desf.) Fruit against CCl4-Induced Acute Liver Injury in Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150383
Modern Language Association (MLA)
Bencheikh, Noureddine…[et al.]. Protective Effect of Zizyphus lotus L. (Desf.) Fruit against CCl4-Induced Acute Liver Injury in Rat. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150383
American Medical Association (AMA)
Bencheikh, Noureddine& Bouhrim, Mohamed& Kharchoufa, Loubna& Choukri, Mohammed& Bnouham, Mohamed& Elachouri, Mostafa. Protective Effect of Zizyphus lotus L. (Desf.) Fruit against CCl4-Induced Acute Liver Injury in Rat. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150383