Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report
Joint Authors
Tsuboi, Nobuo
Yokoo, Takashi
Komatsuzaki, Yo
Nakada, Yasuyuki
Yamamoto, Izumi
Kawabe, Mayuko
Yamakawa, Takafumi
Katsuma, Ai
Katsumata, Haruki
Mafune, Aki
Kobayashi, Akimitsu
Koike, Yusuke
Yamada, Hiroki
Miki, Jun
Tanno, Yudo
Ohkido, Ichiro
Yokoyama, Keitaro
Yamamoto, Hiroyasu
Source
Case Reports in Transplantation
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Despite the recent development of immunosuppressive agents, plasma cell-rich acute rejection (PCAR) has remained refractory to treatment.
Herein, we report an unusual case of PCAR that responded well to pulse steroid therapy alone.
A 47-year-old man was admitted for a protocol biopsy three months after kidney transplantation, with a stable serum creatinine level of 1.6 mg/dL.
Histological examination showed focal aggressive tubulointerstitial inflammatory cell infiltration of predominantly polyclonal mature plasma cells, leading to our diagnosis of PCAR.
Three months following three consecutive days of high-dose methylprednisolone (mPSL) therapy, an allograft biopsy performed for therapy evaluation showed persistent PCAR.
We readministered mPSL therapy and successfully resolved the PCAR.
Although PCAR generally develops more than six months after transplantation, we diagnosed this case early, at three months after transplantation, with focally infiltrated PCAR.
This case demonstrates the importance of early diagnosis and prompt treatment of PCAR to manage the development and severity of allograft rejection.
American Psychological Association (APA)
Komatsuzaki, Yo& Nakada, Yasuyuki& Yamamoto, Izumi& Kawabe, Mayuko& Yamakawa, Takafumi& Katsuma, Ai…[et al.]. 2017. Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report. Case Reports in Transplantation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1150393
Modern Language Association (MLA)
Komatsuzaki, Yo…[et al.]. Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report. Case Reports in Transplantation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1150393
American Medical Association (AMA)
Komatsuzaki, Yo& Nakada, Yasuyuki& Yamamoto, Izumi& Kawabe, Mayuko& Yamakawa, Takafumi& Katsuma, Ai…[et al.]. Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report. Case Reports in Transplantation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1150393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150393