Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology
Joint Authors
Dela Cruz, Nester
Mirza, Rusella
Herrera, Guillermo A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-17
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare primary adenocarcinoma of nasopharynx.
The immunohistochemical pattern of this tumor is similar to that of papillary thyroid carcinoma making this neoplasm a challenging diagnosis.
A case of TL-LGNPPA with biphasic morphology is presented.
The removed tumor from the nasopharynx exhibited a polypoid appearance.
Microscopically, it was composed of papillary structures admixed with a few solid areas of spindle cells.
The papillae were lined by columnar epithelium.
Both the epithelium and the spindle cells were strongly positive for TTF-1 and CK19 and negative for CK5/6, S-100, and thyroglobulin.
Cellular atypia, necrosis, and high mitotic rate were absent.
Ki67 was less than 2% in the neoplastic cells.
No local recurrence or distant metastasis was reported after 12 months of follow-up.
Caution should be taken to differentiate TL-LGPPA from other TTF-1-positive neoplasms, especially papillary thyroid carcinoma, as the prognosis for these two tumors is entirely different.
American Psychological Association (APA)
Mirza, Rusella& Dela Cruz, Nester& Herrera, Guillermo A.. 2020. Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology. Case Reports in Pathology،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1150407
Modern Language Association (MLA)
Mirza, Rusella…[et al.]. Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology. Case Reports in Pathology No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1150407
American Medical Association (AMA)
Mirza, Rusella& Dela Cruz, Nester& Herrera, Guillermo A.. Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology. Case Reports in Pathology. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1150407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150407