Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature
Joint Authors
Troncon, Irene
Guerriero, Angela
Rossi, Sabrina
Ronzon, Monica
Padovan, Marta
Mario, Caccese
Zanatta, Lucia
Toffolatti, Luisa
Marton, Elisabetta
Dei Tos, Angelo Paolo
Canova, Giuseppe
Lombardi, Giuseppe
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults.
Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation.
Here, we describe the case of a previously healthy 47-year-old woman with multiple posterior fossa cerebellar tumors.
Histological, immunohistochemical, and molecular analyses were performed to best characterize the two excised lesions.
The histopathological analysis revealed different variants of medulloblastoma in the excised nodules, one being extensive nodularity, rare in adults, and the other desmoplastic/nodular with areas of anaplasia.
Immunostains and molecular analysis classified both nodules as SHH medulloblastoma.
Adult medulloblastoma is extremely rare.
Important differences exist between adult medulloblastoma and medulloblastoma arising in children and infants.
Such differences are in location, distribution of histological variants and of molecular subgroups, survival rates, and therapeutic options.
An extensive morphological and molecular characterization of such rare tumors is necessary to choice the best-tailored therapy.
American Psychological Association (APA)
Troncon, Irene& Guerriero, Angela& Rossi, Sabrina& Ronzon, Monica& Padovan, Marta& Mario, Caccese…[et al.]. 2020. Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature. Case Reports in Pathology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1150418
Modern Language Association (MLA)
Troncon, Irene…[et al.]. Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature. Case Reports in Pathology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1150418
American Medical Association (AMA)
Troncon, Irene& Guerriero, Angela& Rossi, Sabrina& Ronzon, Monica& Padovan, Marta& Mario, Caccese…[et al.]. Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature. Case Reports in Pathology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1150418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150418