![](/images/graphics-bg.png)
Potential Therapeutic Effects of Underground Parts of Kalanchoe gastonis-bonnieri on Benign Prostatic Hyperplasia
Joint Authors
Costa, Sônia Soares
Meireles Da Costa, Nathalia
Nasciutti, Luiz Eurico
Palumbo, Antonio
Casanova, Livia Marques
Corrêa, Maria Fernanda Paresqui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Benign Prostatic Hyperplasia (BPH) affects mainly older men.
It is estimated to affect 50% of 51-60-year-old men and 70% of 61-70-year-old men.
BPH is a nonmalignant proliferation of epithelial and stromal cells of the prostate gland regions.
Despite the use of conventional pharmacological therapy, herbal medicines are used in BPH therapy, and several mechanisms of action have been suggested based on their complex chemical composition.
Considering the ethnomedicinal uses of Kalanchoe gastonis-bonnieri (KGB), we evaluated the inhibitory effects on the proliferation of stromal cells from primary benign prostatic hyperplasia (BPH) of four different aqueous extracts from this plant: underground parts from specimens in flower (T1 treatment), leaves from specimens in flower (T2 treatment), and flowers (T3 treatment) and leaves from specimens not in flower (T4 treatment).
T1, T2, T3, and T4 treatments at 250 μg/ml for 72 hours inhibited BPH cells by 56.7%, 29.2%, 39.4%, and 13.5%, respectively, showing that the KGB underground parts extract (T1 treatment) was the most active.
Our findings show that the extract of the KGB underground parts (150 and 250 μg/ml) stimulates important changes in the BPH cells, modulating crucial processes such as proliferation, viability, and apoptosis.
HPLC-DAD-MS/MS analysis provided a tentative identification of glycosylated syringic acid derivatives, glycosylated forms of volatile compounds, and lignans in this extract.
Finally, these results suggest that there is a potential therapeutic use for KGB in BPH, which could improve the clinical management of the disease.
American Psychological Association (APA)
Palumbo, Antonio& Casanova, Livia Marques& Corrêa, Maria Fernanda Paresqui& Meireles Da Costa, Nathalia& Nasciutti, Luiz Eurico& Costa, Sônia Soares. 2019. Potential Therapeutic Effects of Underground Parts of Kalanchoe gastonis-bonnieri on Benign Prostatic Hyperplasia. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150463
Modern Language Association (MLA)
Palumbo, Antonio…[et al.]. Potential Therapeutic Effects of Underground Parts of Kalanchoe gastonis-bonnieri on Benign Prostatic Hyperplasia. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1150463
American Medical Association (AMA)
Palumbo, Antonio& Casanova, Livia Marques& Corrêa, Maria Fernanda Paresqui& Meireles Da Costa, Nathalia& Nasciutti, Luiz Eurico& Costa, Sônia Soares. Potential Therapeutic Effects of Underground Parts of Kalanchoe gastonis-bonnieri on Benign Prostatic Hyperplasia. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150463