Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient
Joint Authors
Johnson, David W.
Chan, Samuel
Burke, Michael T.
Francis, Ross S.
Mudge, David W.
Source
Case Reports in Transplantation
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The immunosuppressant tacrolimus has a narrow therapeutic window, necessitating therapeutic drug monitoring to maintain efficacy and minimise toxicity.
There are very few reports examining the impact of impaired biliary excretion on tacrolimus blood levels or toxicity.
We report the case of a 26-year-old combined liver and kidney transplant recipient, who developed acute biliary obstruction leading to tacrolimus toxicity with very high blood tacrolimus levels.
Despite a careful evaluation, no alternative cause was found for her acute kidney injury, and her kidney function returned to previous baseline within several days following treatment of the biliary obstruction and temporary withdrawal of tacrolimus.
American Psychological Association (APA)
Chan, Samuel& Burke, Michael T.& Johnson, David W.& Francis, Ross S.& Mudge, David W.. 2017. Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient. Case Reports in Transplantation،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1150471
Modern Language Association (MLA)
Chan, Samuel…[et al.]. Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient. Case Reports in Transplantation No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1150471
American Medical Association (AMA)
Chan, Samuel& Burke, Michael T.& Johnson, David W.& Francis, Ross S.& Mudge, David W.. Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient. Case Reports in Transplantation. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1150471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150471