Moxibustion of Zusanli (ST36) and Shenshu (BL23) Alleviates Cartilage Degradation through RANKLOPG Signaling in a Rabbit Model of Rheumatoid Arthritis
Joint Authors
Chen, Yang
Li, Haijun
Luo, Xiaochao
Liu, Huahui
Zhong, Yumei
Wu, Xiao
Liu, Xuguang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a systemic and chronic autoimmune inflammatory disease characterized by severe synovial hyperplasia associated with progressive cartilage degradation.
Due to the severe pain and disability caused by RA, effective therapeutic strategies that could simultaneously alleviate the inflammatory response and delay the disease progression are urgently needed.
As a major alternative therapy in traditional Chinese medicine, moxibustion has been demonstrated that it could reduce the chronic inflammatory responses of a series of musculoskeletal diseases; however, whether moxibustion has protective effects on RA is still unclear.
To investigate the effects of moxibustion on RA, moxibustion was applied to Zusanli (ST36) and Shenshu (BL23) acupoints in a RA rabbit model.
HE staining of articular cartilage showed that moxibustion alleviated the cartilage degradation and bone destruction.
In addition, moxibustion decreased the osteoclast number in RA rabbits.
Real-time PCR revealed that moxibustion decreased the expression of RANKL mRNA while increased the expression of OPG mRNA, indicating a restoration of the balance between osteogenesis and osteoclastogenesis.
Taken together, our results indicated that moxibustion had promising antiarthritic effects and could be an useful alternative method in RA therapeutics.
American Psychological Association (APA)
Chen, Yang& Li, Haijun& Luo, Xiaochao& Liu, Huahui& Zhong, Yumei& Wu, Xiao…[et al.]. 2019. Moxibustion of Zusanli (ST36) and Shenshu (BL23) Alleviates Cartilage Degradation through RANKLOPG Signaling in a Rabbit Model of Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1150503
Modern Language Association (MLA)
Chen, Yang…[et al.]. Moxibustion of Zusanli (ST36) and Shenshu (BL23) Alleviates Cartilage Degradation through RANKLOPG Signaling in a Rabbit Model of Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1150503
American Medical Association (AMA)
Chen, Yang& Li, Haijun& Luo, Xiaochao& Liu, Huahui& Zhong, Yumei& Wu, Xiao…[et al.]. Moxibustion of Zusanli (ST36) and Shenshu (BL23) Alleviates Cartilage Degradation through RANKLOPG Signaling in a Rabbit Model of Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1150503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150503