Plasmablastic Lymphoma Associated with Adjacent Mature Plasma Cell Population Exhibiting Opposite Light Chain Restriction
Joint Authors
Miller, Ira
Furlan, Karina
Mahon, Brett
Ocampo Gonzalez, Fernando A.
Ward, Nicholas
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Plasmablastic lymphoma (PBL) is an aggressive high-grade B cell lymphoma, considered a variant of diffuse large B cell lymphoma with approximately 75% mortality within 6-7 months.
We describe an unusual case of PBL arising as a maxillary mass in an HIV-negative, nontransplanted 78-year-old female.
Histologic examination revealed a diffuse infiltrate of anaplastic appearing cells exhibiting plasmablastic morphology with an adjacent contiguous infiltrate of mature appearing plasma cells.
The PBL and mature plasma cell components both demonstrated an immunophenotype of CD20(-), CD38(+), and CD138(+).
The two populations differed by the PBL featuring a high proliferation rate by Ki-67 (~95%) with coexpression of both c-MYC and EBV, while the mature plasma cell component featured a low proliferation rate by Ki-67 (~5%) without coexpression of c-MYC or EBV.
Kappa/lambda staining demonstrated lambda light chain restriction involving the PBL, while the mature plasma cell infiltrate revealed kappa light chain restriction.
Our findings describe the rare association of PBL with a synchronous distinct population of mature plasma cells exhibiting opposite light chain restriction.
American Psychological Association (APA)
Furlan, Karina& Miller, Ira& Mahon, Brett& Ocampo Gonzalez, Fernando A.& Ward, Nicholas. 2020. Plasmablastic Lymphoma Associated with Adjacent Mature Plasma Cell Population Exhibiting Opposite Light Chain Restriction. Case Reports in Pathology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1150522
Modern Language Association (MLA)
Furlan, Karina…[et al.]. Plasmablastic Lymphoma Associated with Adjacent Mature Plasma Cell Population Exhibiting Opposite Light Chain Restriction. Case Reports in Pathology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1150522
American Medical Association (AMA)
Furlan, Karina& Miller, Ira& Mahon, Brett& Ocampo Gonzalez, Fernando A.& Ward, Nicholas. Plasmablastic Lymphoma Associated with Adjacent Mature Plasma Cell Population Exhibiting Opposite Light Chain Restriction. Case Reports in Pathology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1150522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150522