Ginsenoside Rg3 Attenuates Angiotensin II-Mediated Renal Injury in Rats and Mice by Upregulating Angiotensin-Converting Enzyme 2 in the Renal Tissue
Joint Authors
Yu, Xiao-feng
Li, Min
Sui, Da-yuan
Liu, Hui
Jiang, Yichuan
Fu, Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Angiotensin II- (Ang II-) mediated renal injury represents a major pathogenetic mechanism in most chronic kidney diseases.
Our previous research demonstrated that ginsenoside Rg3 (Rg3) attenuates Ang II elevation in the myocardium in spontaneously hypertensive rats (SHR).
It is possible that Rg3 has similar effects in the renal tissue.
In this research, we first demonstrated that Rg3 could attenuate Ang II increase in the kidney of SHR and reduce hypertensive nephropathy progression.
Then, we found that Rg3 attenuated Ang II increase by upregulating angiotensin-converting enzyme 2 (ACE2) in the renal tissue.
We confirmed this finding in an exogenous Ang II-infused mice model of renal injury, and two models showed consistent results.
In conclusion, Rg3 attenuates Ang II-mediated renal injury in rats and mice by upregulating ACE2 in the renal tissue.
This research is the first to demonstrate that Rg3 increases tissue ACE2 levels in vivo.
American Psychological Association (APA)
Liu, Hui& Jiang, Yichuan& Li, Min& Yu, Xiao-feng& Sui, Da-yuan& Fu, Li. 2019. Ginsenoside Rg3 Attenuates Angiotensin II-Mediated Renal Injury in Rats and Mice by Upregulating Angiotensin-Converting Enzyme 2 in the Renal Tissue. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1150611
Modern Language Association (MLA)
Liu, Hui…[et al.]. Ginsenoside Rg3 Attenuates Angiotensin II-Mediated Renal Injury in Rats and Mice by Upregulating Angiotensin-Converting Enzyme 2 in the Renal Tissue. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1150611
American Medical Association (AMA)
Liu, Hui& Jiang, Yichuan& Li, Min& Yu, Xiao-feng& Sui, Da-yuan& Fu, Li. Ginsenoside Rg3 Attenuates Angiotensin II-Mediated Renal Injury in Rats and Mice by Upregulating Angiotensin-Converting Enzyme 2 in the Renal Tissue. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1150611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150611
