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Electroacupuncture Relieves CCI-Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters
Joint Authors
Lin, Yi-Wen
Huang, Chun-Ping
Lee, Der-Yen
Hsieh, Ching-Liang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neuropathic pain caused by peripheral tissue injuries to the higher brain regions still has no satisfactory therapy.
Disruption of the balance of excitatory and inhibitory neurotransmitters is one of the underlying mechanisms that results in chronic neuropathic pain.
Targeting neurotransmitters and related receptors may constitute a novel approach for treating neuropathic pain.
We investigated the effects of electroacupuncture (EA) on chronic constriction injury- (CCI-) induced neuropathic pain.
The mechanical allodynia and thermal hyperalgesia pain behaviors were relieved by 15 Hz EA but not by 2 and 50 Hz.
These phenomena were associated with increasing γ-amino-butyric acid (GABA) receptors in the hippocampus and periaqueductal gray (PAG) but not N-methyl-D-aspartate receptors.
Furthermore, excitatory neurotransmitter glutamate was decreased in the hippocampus and inhibitory neurotransmitter GABA was increased in the PAG under treatment with EA.
These data provide novel evidence that EA modulates neurotransmitters and related receptors to reduce neuropathic pain in the higher brain regions.
This suggests that EA may be a useful therapy option for treating neuropathic pain.
American Psychological Association (APA)
Huang, Chun-Ping& Lin, Yi-Wen& Lee, Der-Yen& Hsieh, Ching-Liang. 2019. Electroacupuncture Relieves CCI-Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150623
Modern Language Association (MLA)
Huang, Chun-Ping…[et al.]. Electroacupuncture Relieves CCI-Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150623
American Medical Association (AMA)
Huang, Chun-Ping& Lin, Yi-Wen& Lee, Der-Yen& Hsieh, Ching-Liang. Electroacupuncture Relieves CCI-Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150623