Study on Pharmacokinetic and Bioavailability of Tamarixetin after Intravenous and Oral Administration to Rats
Joint Authors
Chang, Yanxu
He, Jun
Ma, Wenjuan
Yao, Guangzhe
Jia, Qi
Ouyang, Huizi
Huang, Xuhua
Shen, Jiayuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In this study, a sensitive and reliable HPLC-MS/MS method was established to quantify tamarixetin in rat plasma.
This method was then applied to research on the pharmacokinetic and bioavailability of tamarixetin after intravenous and oral administration in vivo.
The study was performed on CORTECS C18 column (4.6 mm × 150 mm, 2.7 μm) using mobile phase composed of methanol-water-formic acid (85 : 15 : 0.1, v/v) at a flow rate of 0.3 mL/min by a tandem mass system with an electrospray ionization (ESI) source in the negative multiple-reaction monitoring (MRM) mode.
The calibration curves showed good linearity in the range of 5–4000 ng/mL.
The intra- and interday precision of tamarixetin was less than 8.7% and 4.8%, respectively, and accuracy was within ±9.5%.
Extraction recovery (91.4–100.0%) and matrix effect (99.4–107.4%) met the guidelines published by regulatory authorities.
The oral bioavailability of tamarixetin was 20.3 ± 12.4%.
American Psychological Association (APA)
Shen, Jiayuan& Jia, Qi& Huang, Xuhua& Yao, Guangzhe& Ma, Wenjuan& Chang, Yanxu…[et al.]. 2019. Study on Pharmacokinetic and Bioavailability of Tamarixetin after Intravenous and Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1150671
Modern Language Association (MLA)
Shen, Jiayuan…[et al.]. Study on Pharmacokinetic and Bioavailability of Tamarixetin after Intravenous and Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1150671
American Medical Association (AMA)
Shen, Jiayuan& Jia, Qi& Huang, Xuhua& Yao, Guangzhe& Ma, Wenjuan& Chang, Yanxu…[et al.]. Study on Pharmacokinetic and Bioavailability of Tamarixetin after Intravenous and Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1150671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150671
