Acute Megakaryoblastic Leukemia with Trisomy 21 and Tetrasomy 21 Clones in a Phenotypically Normal Child with Mosaic Trisomy 21
Joint Authors
Won, Eric
Gruber, Tanja A.
Tucker, Suzanne
Schiff, Deborah E.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Pediatric acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML) that may be divided into two subgroups: (1) Down syndrome- (DS-) related AMKL which generally has a favorable prognosis and (2) non-DS-related AMKL which generally has a poorer outcome.
We report a phenotypically normal child with AMKL with trisomy 21 (T21) and tetrasomy 21 clones.
Subsequently, she was diagnosed with mosaic T21.
She underwent reduced-intensity therapy with good outcome.
We review the literature regarding AMKL-associated cytogenetic abnormalities and AMKL in association with DS.
We suggest evaluation for mosaic T21 in phenotypically normal pediatric patients with T21-positive AML.
American Psychological Association (APA)
Won, Eric& Gruber, Tanja A.& Tucker, Suzanne& Schiff, Deborah E.. 2020. Acute Megakaryoblastic Leukemia with Trisomy 21 and Tetrasomy 21 Clones in a Phenotypically Normal Child with Mosaic Trisomy 21. Case Reports in Pediatrics،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1150693
Modern Language Association (MLA)
Won, Eric…[et al.]. Acute Megakaryoblastic Leukemia with Trisomy 21 and Tetrasomy 21 Clones in a Phenotypically Normal Child with Mosaic Trisomy 21. Case Reports in Pediatrics No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1150693
American Medical Association (AMA)
Won, Eric& Gruber, Tanja A.& Tucker, Suzanne& Schiff, Deborah E.. Acute Megakaryoblastic Leukemia with Trisomy 21 and Tetrasomy 21 Clones in a Phenotypically Normal Child with Mosaic Trisomy 21. Case Reports in Pediatrics. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1150693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150693
