Pardaxin Promoted Differentiation and Maturation of Leukemic Cells via Regulating TLR2MyD88 Signal against Cell Proliferation
Joint Authors
Choong, Chen-Yen
Uen, Wu-Ching
Tai, Chen-Jei
Tai, Cheng-Jeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Leukemia is a cancer of the blood cells.
Leukemic THP-1 and U937 cells were used in this study as monocytic effectors cells for proliferation responses and macrophage-like cells induction in leukemia.
Pardaxin is an antimicrobial peptide isolated from the marine fish species.
Methods.
After treatment for 5 days, pardaxin significantly suppressed cell viability and arrested cell cycle at G0/G1 phase in leukemic cells which were evaluated.
Results.
Pardaxin also induced cell differentiation and maturation of THP-1 and U937 cells into macrophage-like cells with phagocytotic ability.
Moreover, pardaxin elevated the expression of MyD88 but not toll-like receptor (TLR)-2 in both leukemic cells.
TLR-2 blocking peptide was used to confirm that pardaxin attenuated phagocytotic ability and superoxide anion production in leukemic cells via activating MyD88 protein.
Conclusions.
These findings suggested that pardaxin has a therapeutic potential for leukemia.
American Psychological Association (APA)
Uen, Wu-Ching& Choong, Chen-Yen& Tai, Chen-Jei& Tai, Cheng-Jeng. 2019. Pardaxin Promoted Differentiation and Maturation of Leukemic Cells via Regulating TLR2MyD88 Signal against Cell Proliferation. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150713
Modern Language Association (MLA)
Uen, Wu-Ching…[et al.]. Pardaxin Promoted Differentiation and Maturation of Leukemic Cells via Regulating TLR2MyD88 Signal against Cell Proliferation. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150713
American Medical Association (AMA)
Uen, Wu-Ching& Choong, Chen-Yen& Tai, Chen-Jei& Tai, Cheng-Jeng. Pardaxin Promoted Differentiation and Maturation of Leukemic Cells via Regulating TLR2MyD88 Signal against Cell Proliferation. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150713