Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives

Joint Authors

Collum, Scott D.
Amione-Guerra, Javier
Cruz-Solbes, Ana S.
DiFrancesco, Amara
Hernandez, Adriana M.
Hanmandlu, Ankit
Youker, Keith
Guha, Ashrith
Karmouty-Quintana, Harry

Source

Canadian Respiratory Journal

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-02-13

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases
Medicine

Abstract EN

Pulmonary hypertension (PH) is commonly present in patients with chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD) or Idiopathic Pulmonary Fibrosis (IPF) where it is classified as Group III PH by the World Health Organization (WHO).

PH has been identified to be present in as much as 40% of patients with COPD or IPF and it is considered as one of the principal predictors of mortality in patients with COPD or IPF.

However, despite the prevalence and fatal consequences of PH in the setting of chronic lung diseases, there are limited therapies available for patients with Group III PH, with lung transplantation remaining as the most viable option.

This highlights our need to enhance our understanding of the molecular mechanisms that lead to the development of Group III PH.

In this review we have chosen to focus on the current understating of PH in IPF, we will revisit the main mediators that have been shown to play a role in the development of the disease.

We will also discuss the experimental models available to study PH associated with lung fibrosis and address the role of the right ventricle in IPF.

Finally we will summarize the current available treatment options for Group III PH outside of lung transplantation.

American Psychological Association (APA)

Collum, Scott D.& Amione-Guerra, Javier& Cruz-Solbes, Ana S.& DiFrancesco, Amara& Hernandez, Adriana M.& Hanmandlu, Ankit…[et al.]. 2017. Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives. Canadian Respiratory Journal،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1150776

Modern Language Association (MLA)

Collum, Scott D.…[et al.]. Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives. Canadian Respiratory Journal No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1150776

American Medical Association (AMA)

Collum, Scott D.& Amione-Guerra, Javier& Cruz-Solbes, Ana S.& DiFrancesco, Amara& Hernandez, Adriana M.& Hanmandlu, Ankit…[et al.]. Pulmonary Hypertension Associated with Idiopathic Pulmonary Fibrosis: Current and Future Perspectives. Canadian Respiratory Journal. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1150776

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1150776