Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha
Joint Authors
Miaffo, David
Kamanyi, Albert
Wansi Ngnokam, Sylvie Léa
Talba, Mahamad Abba
Poualeu Kamani, Sylviane Laure
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cissus polyantha (Vitaceae) is a plant used in Cameroonian traditional medicine for the treatment of diabetes.
The aims of this study were to evaluate the in vitro antioxidant and antidiabetic activities of the aqueous extract of Cissus polyantha leafy stems.
The enzyme inhibitory activity was determined in vitro on α-amylase and α-glucosidase enzymes, followed by confirmative study in vivo on normal rats (oral starch and sucrose tolerance tests at doses of 111, 222, and 444 mg/kg).
The ferric reducing antioxidant power and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) antiradical activity of the extract were examined to evaluate the antioxidant potential of the extract.
The total content of phenols, flavonoids, and tannins of the extract were also determined.
The results showed an inhibitory effect of the extract on the α-amylase and α-glucosidase activities with IC50 values of 216.14 and 182.40 μg/mL, respectively.
The extract at doses of 222 and 444 mg/kg induced a significant decrease in postprandial glycaemia during the starch and sucrose tolerance tests.
A remarkable antiradical activity of the extract was obtained although lower than that of the standard product.
The aqueous extract of leafy stems of Cissus polyantha has an interesting inhibitory activity on the α-amylase and α-glucosidase enzymes, as well as an antioxidant potential, thus validating its use in traditional medicine for the treatment of diabetes mellitus and its complications.
American Psychological Association (APA)
Talba, Mahamad Abba& Miaffo, David& Poualeu Kamani, Sylviane Laure& Kamanyi, Albert& Wansi Ngnokam, Sylvie Léa. 2019. Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1150826
Modern Language Association (MLA)
Talba, Mahamad Abba…[et al.]. Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1150826
American Medical Association (AMA)
Talba, Mahamad Abba& Miaffo, David& Poualeu Kamani, Sylviane Laure& Kamanyi, Albert& Wansi Ngnokam, Sylvie Léa. Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1150826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150826