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Evaluation of In Vitro Antioxidant and Antidiabetic Activities of Aristolochia longa Extracts
Joint Authors
Kamal, Rabie
Bouyahya, Abdelhakim
Sayah, Karima
Faouzi, My El Abbes
El Omari, Nasreddine
Fettach, Saad
El Blidi, Omar
Barkiyou, Malika
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress plays a major role in diabetic physiopathology; hence, the interest of using natural antioxidants as therapeutic tools exists.
The aim of this study was the evaluation of in vitro antioxidant activity and inhibitory potential of organic extracts from Aristolochia longa roots against key enzymes linked to hyperglycemia.
Antioxidant activity was performed using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals and ferric reducing/antioxidant power (FRAP) methods.
The α-Glucosidase and β-Galactosidase inhibitory activities were investigated using an in vitro model.
Moreover, phytochemical analysis of tested extracts was carried out.
The aqueous fraction of this herb exhibited the highest antioxidant activity for both DPPH and ABTS methods, IC50=125.40±2.40 μg/mL and IC50=65.23±2.49 μg/mL, respectively.
However, the ethyl acetate fraction possessed the strongest inhibitory effect towards α-Glucosidase (IC50=1.112±0.026 mg/mL).
Furthermore, the result showed high levels of phenolic content.
The results showed that this plant could be a significant source of medically important natural compounds.
American Psychological Association (APA)
El Omari, Nasreddine& Sayah, Karima& Fettach, Saad& El Blidi, Omar& Bouyahya, Abdelhakim& Faouzi, My El Abbes…[et al.]. 2019. Evaluation of In Vitro Antioxidant and Antidiabetic Activities of Aristolochia longa Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150830
Modern Language Association (MLA)
El Omari, Nasreddine…[et al.]. Evaluation of In Vitro Antioxidant and Antidiabetic Activities of Aristolochia longa Extracts. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150830
American Medical Association (AMA)
El Omari, Nasreddine& Sayah, Karima& Fettach, Saad& El Blidi, Omar& Bouyahya, Abdelhakim& Faouzi, My El Abbes…[et al.]. Evaluation of In Vitro Antioxidant and Antidiabetic Activities of Aristolochia longa Extracts. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150830