Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila

Abstract EN

In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese herbal medicine for insomnia.

Short-term insomnia and hypnotic use both attenuate cognitive functions, especially learning memory.

In previous studies, A.

julibrissin exhibits sedative activity, antidepressant-like effects, and protection of learning and memory against amnesia.

However, whether A.

julibrissin ameliorates memory loss caused by short-term sleep deprivation is not clear.

We utilized the sleep-deprived Drosophila model and olfactory associative learning-memory assay to test the effects of A.

julibrissin on sleep-deprivation induced memory loss.

We found that A.

julibrissin ameliorated 3-hour memory but not 1-hour memory or instant learning.

The findings might be applied to an anticipated short-term sleep disturbance.