Hepatic Failure following Metronidazole in Children with Cockayne Syndrome
Joint Authors
Ataee, Pedram
karimi, Avat
Eftekhari, K.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Cockayne syndrome is an uncommon autosomal recessive disease characterized by microcephaly, abnormal growth, and pathologic premature aging.
The purpose of this report is to evaluate liver failure in children with Cockayne syndrome following metronidazole administration.
The first case was a 2-year-old boy with Cockayne syndrome.
He had been treated with metronidazole for gastroenteritis.
48 hours after treatment initiation, he was hospitalized due to jaundice, intractable vomiting, and agitation.
Unfortunately, he died of acute liver failure.
The second case was a 5-year-old boy with Cockayne syndrome as well, who had been treated with amoxicillin and metronidazole for a dental infection.
He developed jaundice, drowsiness, lethargy, and anorexia after treatment.
At hospital, the child received supportive treatment, and his general condition gradually improved.
The liver enzyme levels decreased.
He was finally discharged in good general condition.
The mortality after metronidazole consumption in patients with Cockayne syndrome due to liver failure is very high.
The awareness of the dangers of using metronidazole in these patients is valuable.
American Psychological Association (APA)
Ataee, Pedram& karimi, Avat& Eftekhari, K.. 2020. Hepatic Failure following Metronidazole in Children with Cockayne Syndrome. Case Reports in Pediatrics،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1150856
Modern Language Association (MLA)
Ataee, Pedram…[et al.]. Hepatic Failure following Metronidazole in Children with Cockayne Syndrome. Case Reports in Pediatrics No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1150856
American Medical Association (AMA)
Ataee, Pedram& karimi, Avat& Eftekhari, K.. Hepatic Failure following Metronidazole in Children with Cockayne Syndrome. Case Reports in Pediatrics. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1150856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150856