![](/images/graphics-bg.png)
Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine
Joint Authors
Rivas Morales, Catalina
Leos-Rivas, Catalina
Verde-Star, Maria Julia
Nuñez-Gonzalez, Maria Adriana
Sánchez-García, Eduardo
González-Yáñez, Ma G. E.
Oranday-Cárdenas, María A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is a trend to use medicinal plants for primary medical care or as dietary supplements; however, the safety of many of these plants has not been studied.
The objective of this work was to determine the toxic effect of the aqueous extract of Calea ternifolia (C.
zacatechichi), known popularly as “dream herb” in vivo and in vitro in order to validate its safety.
In vivo, the extract had moderate toxicity on A.
salina.
In vitro, the extract induced eryptosis of 73% at a concentration of 100 μg·mL−1 and it inhibited CYP3A by 99% at a concentration of 375 μg/mL.
After administering 8.5 mg/kg of C.
ternifolia to rats, we found a reduction in platelets and leukocytes and an increase in urea and the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP).
Histological analysis showed spongiform changes in the proximal tubules of renal tissue and a lymphoid infiltrate in liver tissue.
This plant is used in the treatment of diabetes, and it is commercialized as a dietary supplement in several countries.
Our results show renal and hepatic toxicity; therefore, more profound research on the toxicity of this plant is needed.
American Psychological Association (APA)
González-Yáñez, Ma G. E.& Rivas Morales, Catalina& Oranday-Cárdenas, María A.& Verde-Star, Maria Julia& Nuñez-Gonzalez, Maria Adriana& Sánchez-García, Eduardo…[et al.]. 2019. Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1150882
Modern Language Association (MLA)
González-Yáñez, Ma G. E.…[et al.]. Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1150882
American Medical Association (AMA)
González-Yáñez, Ma G. E.& Rivas Morales, Catalina& Oranday-Cárdenas, María A.& Verde-Star, Maria Julia& Nuñez-Gonzalez, Maria Adriana& Sánchez-García, Eduardo…[et al.]. Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1150882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150882