Persistent Tachycardia in a Patient on Clozapine
Joint Authors
Oladeji, Oluwatoyin
Adeyemo, Samuel
Jegede, Oluwole
Rabel, Peterson
Ahmed, Saad
Tumenta, Terence
Taher, Khanderker
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tachycardia emergent from clozapine treatment is usually transient, often missed, unreported, and therefore frequently goes untreated resulting in possible premature discontinuation of an otherwise effective treatment.
Clozapine-induced tachycardia results from direct effects on the sympathetic nervous system including the blockade of cardiac muscarinic M2 receptors, presynaptic α2 adrenoceptors, and indirect activation of the β adrenoceptors.
Unfortunately, there are no clear guidelines for monitoring or treating tachycardia induced by clozapine.
We present a case of a 55-year-old man with treatment-resistant schizophrenia initiated on clozapine who developed persistent tachycardia and right bundle branch block in the course of treatment.
Tachycardia persisted despite treatment with metoprolol and necessitated a transfer to the intensive care unit.
A reduction in clozapine dose with the addition of adjunctive antipsychotic(lurasidone) stabilized the patient’s heart rate.
This case highlights the need for consistent physical examination and a multidisciplinary-based treatment approach for patients on clozapine.
The case also suggests that clozapine dose reduction and combination antipsychotic treatments may preclude the need to discontinue clozapine in patients with persistent tachycardia.
American Psychological Association (APA)
Adeyemo, Samuel& Jegede, Oluwole& Rabel, Peterson& Ahmed, Saad& Tumenta, Terence& Oladeji, Oluwatoyin…[et al.]. 2020. Persistent Tachycardia in a Patient on Clozapine. Case Reports in Psychiatry،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1150912
Modern Language Association (MLA)
Adeyemo, Samuel…[et al.]. Persistent Tachycardia in a Patient on Clozapine. Case Reports in Psychiatry No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1150912
American Medical Association (AMA)
Adeyemo, Samuel& Jegede, Oluwole& Rabel, Peterson& Ahmed, Saad& Tumenta, Terence& Oladeji, Oluwatoyin…[et al.]. Persistent Tachycardia in a Patient on Clozapine. Case Reports in Psychiatry. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1150912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150912