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Enhancement of Endometrial Receptivity by Cnidium officinale through Expressing LIF and Integrins
Joint Authors
Kim, Keuk-Jun
Lee, Hoyoung
Ha, Ki-Tae
Chung, Tae-Wook
Park, Mi-Ju
Choi, Hee-Jung
Kim, Cheorl-Ho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Improvement of endometrial receptivity is necessary for successful embryo implantation, and its impairment is associated with female infertility.
In this study, we investigated the effect of the roots of Cnidium officinale Makino (CoM) on endometrial receptivity in both in vitro and in vivo model of embryo implantation.
We found that CoM enhanced the adhesion of JAr cells to Ishikawa cells by stimulating expression of leukemia inhibitory factor (LIF) and integrins.
In addition, blocking of LIFR using hLA or neutralization of integrins αV, β3, and β5 using antibodies significantly reduced the enhanced adhesion between JAr cell and CoM-treated Ishikawa cells, indicating that LIF and integrin play an important role in trophoblast-endometrium adhesion for embryo implantation.
Furthermore, we identified that CoM significantly improved the implantation rate of blastocysts in the mouse model of RU-induced implantation failure.
By collecting these results, here, we suggest that CoM has a therapeutic potential against female infertility associated with decreased endometrial receptivity.
American Psychological Association (APA)
Chung, Tae-Wook& Park, Mi-Ju& Lee, Hoyoung& Kim, Keuk-Jun& Kim, Cheorl-Ho& Choi, Hee-Jung…[et al.]. 2019. Enhancement of Endometrial Receptivity by Cnidium officinale through Expressing LIF and Integrins. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150976
Modern Language Association (MLA)
Chung, Tae-Wook…[et al.]. Enhancement of Endometrial Receptivity by Cnidium officinale through Expressing LIF and Integrins. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150976
American Medical Association (AMA)
Chung, Tae-Wook& Park, Mi-Ju& Lee, Hoyoung& Kim, Keuk-Jun& Kim, Cheorl-Ho& Choi, Hee-Jung…[et al.]. Enhancement of Endometrial Receptivity by Cnidium officinale through Expressing LIF and Integrins. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150976