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Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism
Joint Authors
Li, Hao
Sang, Lan
Xia, Xing
Zhao, Ruirui
Wang, Mingyue
Hou, Xiaofei
Xiong, Jiawei
Cao, Tiemin
Liu, Xiaoquan
Zhang, Jianbin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Moxibustion has been widely accepted as an alternative therapy for major depressive disease (MDD).
However, the efficacy of moxibustion treatment on MDD is highly variable because of its irregular operation.
This study was designed to investigate how therapeutic duration and extent influence the anti-depression effect of moxibustion and the underlying mechanism involved.
Rats with lipopolysaccharide-induced depression-like behavior were treated by moxibustion treatment.
The anti-depression effect was determined by forced swimming test and open field test.
Tryptophan (Trp) transport and its metabolism to serotonin (5-HT) and kynurenine (Kyn) were evaluated to explore the anti-depression mechanism.
The results showed that moxibustion treatment could alleviate the depression-like behavior in rats.
Trp transport and 5-HT generation were significantly increased, and the Trp-Kyn pathway was moderately inhibited by moxibustion.
Prolonged therapy could be beneficial to the anti-depression effect by promoting the brain uptake of Trp and shifting the Trp metabolism to 5-HT.
An enhanced therapeutic extent could increase 5-HT generation.
In conclusion, this study determined that the anti-depression effect of moxibustion involves improved Trp transport and metabolism.
The therapeutic duration benefits antidepressant effects, but the complex influence of the therapeutic extent on moxibustion efficacy requires further studies.
American Psychological Association (APA)
Li, Hao& Sang, Lan& Xia, Xing& Zhao, Ruirui& Wang, Mingyue& Hou, Xiaofei…[et al.]. 2019. Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150992
Modern Language Association (MLA)
Li, Hao…[et al.]. Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1150992
American Medical Association (AMA)
Li, Hao& Sang, Lan& Xia, Xing& Zhao, Ruirui& Wang, Mingyue& Hou, Xiaofei…[et al.]. Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150992