Using Network Pharmacology to Explore Potential Treatment Mechanism for Coronary Heart Disease Using Chuanxiong and Jiangxiang Essential Oils in Jingzhi Guanxin Prescriptions
Joint Authors
Zou, Jun-Bo
Zhang, Xiao-Fei
Shi, Ya-Jun
Tai, Jia
Wang, Yu
Liang, Yu-Lin
Wang, Jing
Guo, Dong-Yan
Wang, Mei
Cui, Chunli
Cheng, Jiangxue
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
To predict the active components and potential targets of traditional Chinese medicine and to determine the mechanism behind the curative effect of traditional Chinese medicine, a multitargeted method was used.
Jingzhi Guanxin prescriptions expressed a high efficacy for coronary heart disease (CHD) patients of which essential oils from Chuanxiong and Jiangxiang were confirmed to be the most important effective substance.
However, the interaction between the active components and the targets for the treatment of CHD has not been clearly explained in previous studies.
Materials and Methods.
Genes associated with the disease and the treatment strategy were searched from the electronic database and analyzed by Cytoscape (version 3.2.1).
Protein-protein interaction network diagram of CHD with Jiangxiang and Chuanxiong essential oils was constructed by Cytoscape.
Pathway functional enrichment analysis was executed by clusterProfiler package in R platform.
Results.
121 ingredients of Chuanxiong and Jiangxiang essential oils were analyzed, and 393 target genes of the compositions and 912 CHD-related genes were retrieved.
15 coexpression genes were selected, including UGT1A1, DPP4, RXRA, ADH1A, RXRG, UGT1A3, PPARA, TRPC3, CYP1A1, ABCC2, AHR, and ADRA2A.
The crucial pathways of occurrence and treatment molecular mechanism of CHD were analyzed, including retinoic acid metabolic process, flavonoid metabolic process, response to xenobiotic stimulus, cellular response to xenobiotic stimulus, cellular response to steroid hormone stimulus, retinoid binding, retinoic acid binding, and monocarboxylic acid binding.
Finally, we elucidate the underlying role and mechanism behind these genes in the pathogenesis and treatment of CHD.
Conclusions.
Generally speaking, the nodes in subnetwork affect the pathological process of CHD, thus indicating the mechanism of Jingzhi Guanxin prescriptions containing Chuanxiong and Jiangxiang essential oils in the treatment of CHD.
American Psychological Association (APA)
Tai, Jia& Zou, Jun-Bo& Zhang, Xiao-Fei& Wang, Yu& Liang, Yu-Lin& Guo, Dong-Yan…[et al.]. 2019. Using Network Pharmacology to Explore Potential Treatment Mechanism for Coronary Heart Disease Using Chuanxiong and Jiangxiang Essential Oils in Jingzhi Guanxin Prescriptions. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151028
Modern Language Association (MLA)
Tai, Jia…[et al.]. Using Network Pharmacology to Explore Potential Treatment Mechanism for Coronary Heart Disease Using Chuanxiong and Jiangxiang Essential Oils in Jingzhi Guanxin Prescriptions. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1151028
American Medical Association (AMA)
Tai, Jia& Zou, Jun-Bo& Zhang, Xiao-Fei& Wang, Yu& Liang, Yu-Lin& Guo, Dong-Yan…[et al.]. Using Network Pharmacology to Explore Potential Treatment Mechanism for Coronary Heart Disease Using Chuanxiong and Jiangxiang Essential Oils in Jingzhi Guanxin Prescriptions. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151028