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Thirteen-Week Oral Toxicity Study of HVC1 in Rats
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Studies on the safety of herbal medicine are essential for the development of new drugs.
The aim of this study was to evaluate the no-observed-adverse-effect-level (NOAEL) of HVC1 (Gamisamhwangsasim-tang, a 30% ethanol extract of a mixture of Pruni Cortex, Scutellariae Radix, Coptidis Rhizoma, and Rhei Rhizoma) and identify its target organs after oral administration to Sprague-Dawley (SD) rats repeatedly for 13 weeks.
Three test groups were treated with HVC1 at a dose of either 500 (low-dose), 1,000 (middle-dose), or 2,000 (high-dose) mg/kg/day.
Another group received high-dose HVC1 and was observed for 4 weeks following treatment to examine recovery from the effects of the extract.
All treatment groups were compared to a vehicle control group.
During the study, mortality, clinical signs, body weight changes, food consumption, abnormal lesions in the eye, urinary parameters, hematological parameters, blood coagulation time, blood biochemical parameters, changes in organ weight, gross findings, and histopathological changes were examined.
No systemic toxicity related to HVC1 was observed in any group, and it was concluded that the NOAEL of HVC1 was 2,000 mg/kg/day.
No target organ was identified.
American Psychological Association (APA)
Lee, Kyungjin& Choi, Ho-Young. 2019. Thirteen-Week Oral Toxicity Study of HVC1 in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151102
Modern Language Association (MLA)
Lee, Kyungjin& Choi, Ho-Young. Thirteen-Week Oral Toxicity Study of HVC1 in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1151102
American Medical Association (AMA)
Lee, Kyungjin& Choi, Ho-Young. Thirteen-Week Oral Toxicity Study of HVC1 in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151102