Uncovering the Anticancer Mechanism of Compound Sophorae Decoction against Ulcerative Colitis-Related Colorectal Cancer in Mice
Joint Authors
Hu, Jian-li
Deng, Shuangjiao
Tang, Qing
Duan, Xueyun
Fan, Heng
Zhang, Lijuan
Zhu, Xiwen
Xu, Meng
Chen, Qianyun
Liu, Yujin
Dong, Yalan
Nan, Zhen
Wu, Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Compound sophorae decoction (CSD), a traditional Chinese medicine (TCM) formula, has been voluminously used in China to deal with ulcerative colitis and gained significant therapeutic effect.
Tremendous explorations have unraveled a contributory role of inflammatory bowel disease (IBD) like ulcerative colitis (UC) and Crohn’s disease (CD) at the onset of colorectal cancer, scilicet, and colitis-related cancer (CRC).
In light of the anti-inflammatory properties of CSD in UC, we appraised its chemoprevention capacity and underlying mechanism in ulcerative colitis-related colorectal cancer (UCRCC), employing a model of azoxymethane (AOM) plus dextran sulfate sodium- (DSS-) induced colorectal cancer (CRC) in C57BL/6 mice.
Rapturously, our results illuminated the ameliorative effect of CSD against UCRCC in mice portrayed by lesser polyps or adenomas, attenuated colonic xenograft tumor growth in company with the preferable well-being of mice in contrast to the Model Group.
We examined significant downregulation of proinflammatory cytokines such as TNF-α, NF-κB, IL-6, STAT3, and IL-17 after exposure to CSD, with the concomitant repression of inflammation-associated proteins, including COX-2 and iNOS.
Independent of this, treatment with CSD declined the proportion of T helper 17 cells (Th17) and protein level of matrix metallopeptidase 9 (MMP-9).
Moreover, transmission electron microscopy (TEM) detected observably suppressed mitophagy in mice administered with CSD and that was paralleled by the pro-apoptotic effect as indicated by upregulating caspase-3 together with caspase-9 and deregulating B-cell lymphoma 2 (Bcl-2).
In closing, these findings suggest CSD executes the UCRCC-inhibitory activity through counteracting inflammatory responses and rescuing detuning of apoptosis as well as neutralizing overactive mitophagy, concurring to build up an oncosuppressive microenvironment.
American Psychological Association (APA)
Deng, Shuangjiao& Tang, Qing& Duan, Xueyun& Fan, Heng& Zhang, Lijuan& Zhu, Xiwen…[et al.]. 2019. Uncovering the Anticancer Mechanism of Compound Sophorae Decoction against Ulcerative Colitis-Related Colorectal Cancer in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1151119
Modern Language Association (MLA)
Deng, Shuangjiao…[et al.]. Uncovering the Anticancer Mechanism of Compound Sophorae Decoction against Ulcerative Colitis-Related Colorectal Cancer in Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1151119
American Medical Association (AMA)
Deng, Shuangjiao& Tang, Qing& Duan, Xueyun& Fan, Heng& Zhang, Lijuan& Zhu, Xiwen…[et al.]. Uncovering the Anticancer Mechanism of Compound Sophorae Decoction against Ulcerative Colitis-Related Colorectal Cancer in Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1151119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151119