Doxycycline-Induced Antinuclear Antibody and Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Case Report and Literature Review
Joint Authors
Chen, Guoli
Wriston, Davisson J.
Norfolk, Evan R.
Smith, Lindsay M.
Bulbin, David H.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Drug-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been increasingly recognized in the literature with numerous medications listed as causative agents in disease pathology.
Doxycycline is a commonly prescribed medication within the United States which is a synthetic, broad-spectrum antibiotic with antimicrobial properties and at low doses exhibits anti-inflammatory effects.
In this report, we describe a case of doxycycline-induced ANCA-associated vasculitis with laboratory and biopsy findings supporting the diagnosis, which to the best of our knowledge is the first described case of doxycycline-induced AAV in the literature.
The patient was started on doxycycline for treatment of potential Lyme disease.
She began to develop progressively worsening myasthenia, erythematous macular rash, anorexia, anemia, and fatigue for several weeks following the course of doxycycline with initial concern of a paraneoplastic process.
Ultimately, the patient was discovered to be positive for antinuclear antibody (ANA), perinuclear antineutrophil cytoplasmic antibody (pANCA), and myeloperoxidase (MPO) antibody for which she was treated with a course of prednisone leading to complete remission of disease.
A brief review of the pathogenesis of ANCA vasculitides will also be discussed within this article.
American Psychological Association (APA)
Wriston, Davisson J.& Norfolk, Evan R.& Smith, Lindsay M.& Chen, Guoli& Bulbin, David H.. 2020. Doxycycline-Induced Antinuclear Antibody and Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Case Report and Literature Review. Case Reports in Rheumatology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1151139
Modern Language Association (MLA)
Wriston, Davisson J.…[et al.]. Doxycycline-Induced Antinuclear Antibody and Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Case Report and Literature Review. Case Reports in Rheumatology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1151139
American Medical Association (AMA)
Wriston, Davisson J.& Norfolk, Evan R.& Smith, Lindsay M.& Chen, Guoli& Bulbin, David H.. Doxycycline-Induced Antinuclear Antibody and Antineutrophil Cytoplasmic Antibody Associated Vasculitis: A Case Report and Literature Review. Case Reports in Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1151139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151139