Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor
Joint Authors
Ohtori, Seiji
Kamoda, Hiroto
Yonemoto, Tsukasa
Ishii, Takeshi
Kinoshita, Hideyuki
Tsukanishi, Toshinori
Hagiwara, Yoko
Hirosawa, Naoya
Orita, Sumihisa
Inage, Kazuhide
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare inflammatory disorder with multiple phenotypes.
The syndrome has identifiable radiologic characteristics that are the most important when making a diagnosis.
X-rays of cases diagnosed with SAPHO syndrome reveal sclerotic lesions or mixed lytic and sclerotic lesions.
Pure osteolytic lesions in SAPHO syndrome are rare, and to the best of our knowledge, no study has reported the radiologic change of purely osteolytic lesions to osteosclerotic lesions over time.
Herein, we report on the case of a woman experiencing severe left thigh acute pain and having a medical history of palmoplantar pustulosis.
Although SAPHO syndrome was suspected because of palmoplantar pustulosis, based on radiologic findings, bone metastasis of a malignant tumor or chronic bacterial osteomyelitis owing to a purely osteolytic lesion was suspected.
However, needle biopsy revealed no malignancy and bacterial culture was negative, thus suggesting SAPHO syndrome.
Nonsteroidal anti-inflammatory drugs, bisphosphonates, and corticosteroids were administered, which improved the left thigh pain.
Furthermore, the radiologic change of osteolytic lesions to osteosclerotic lesions over time was confirmed, leading to the diagnosis of SAPHO syndrome.
Our case demonstrates that knowledge of atypical radiologic findings is necessary to diagnose initial SAPHO syndrome.
American Psychological Association (APA)
Kinoshita, Hideyuki& Ishii, Takeshi& Kamoda, Hiroto& Hagiwara, Yoko& Tsukanishi, Toshinori& Orita, Sumihisa…[et al.]. 2020. Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor. Case Reports in Rheumatology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1151164
Modern Language Association (MLA)
Kinoshita, Hideyuki…[et al.]. Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor. Case Reports in Rheumatology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1151164
American Medical Association (AMA)
Kinoshita, Hideyuki& Ishii, Takeshi& Kamoda, Hiroto& Hagiwara, Yoko& Tsukanishi, Toshinori& Orita, Sumihisa…[et al.]. Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor. Case Reports in Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1151164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151164