Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically
Joint Authors
Hakim, Rachmi Fanani
Fakhrurrazi, Rachmi Fanani
Dinni, Rachmi Fanani
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Wound healing entails a sequence of complex biological processes, which is a protective function of the body that focuses on a quick recovery.
Reducing wound healing time is crucial in a wound as it lowers the chance of infection and decreases complications and costs.
Papaya extract was obtained by a maceration method.
It contains papain enzyme, flavonoid, saponin, and alkaloid, which act as an anti-inflammatory, astringent substance, vasodilator, antioxidant, analgesic, with antifungal, and antibacterial properties, and increase the collagen synthesis.
This study aimed to assess the effect of Carica papaya extract application toward incised wound healing process in mice (Mus musculus) clinically and histologically.
This experimental laboratory study was performed using 24 mice weighing between 30 and 40 grams and 12 and 14 weeks of age as experimental animals.
Each group was incised along 5 mm at the labial gingiva under both of mandible anterior teeth with a depth reaching alveolar bone.
Papaya extract was applied topically in the morning and evening for 14 days.
The clinical result was obtained by assessing the length of wound closure measured every day for 14 days.
Based on the statistic test result, it showed that the papaya extract has a significant effect (p≤0.05) toward the healing process of an incised oral wound in mice.
Histologically at day 14, 75% concentration papaya extract showed perfect epithelial layer and fibrillation.
American Psychological Association (APA)
Hakim, Rachmi Fanani& Fakhrurrazi, Rachmi Fanani& Dinni, Rachmi Fanani. 2019. Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1151179
Modern Language Association (MLA)
Hakim, Rachmi Fanani…[et al.]. Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1151179
American Medical Association (AMA)
Hakim, Rachmi Fanani& Fakhrurrazi, Rachmi Fanani& Dinni, Rachmi Fanani. Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1151179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151179