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Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential
Joint Authors
Kuete, Victor
Mbaveng, Armelle T.
Manekeng, Hermione T.
Ntyam Mendo, Samuel A.
Agokeng, Armel-Joseph D.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The methanol crude extract of the bark of Psidium guajava (guava) previously displayed interesting cytotoxic effects on a panel of human cancer cell lines.
In the present work, we plan to determine the toxicological effects of this guava botanical in Wistar rats.
Acute oral toxicity of the extract was carried out by administration of a single dose of 5000 mg/kg body weight to female rats in 14 days.
Subacute toxicity was conducted by oral administration of the extract at daily doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg body weight, respectively, while rats in the control group received no extract.
After 28 days of treatment, animals were sacrificed for hematological and biochemical studies.
In the acute toxicity study, no mortality or signs of toxicity were recorded; hence, the median lethal dose (LD50) of the Psidium guajava bark extract is greater than 5000 mg/kg body weight.
For the subacute toxicity study, significant variations in body weight, relative weight of organs, and biochemical parameters were observed in the animals treated at different doses of the plant extract compared to control animals.
Histopathological analyses showed minor liver inflammation in females treated at the highest dose (1000 mg/kg).
These results suggest that intake of a single high dose of the Psidium guajava bark extract is nontoxic, but repeat administration could exhibit mild organ toxicity.
American Psychological Association (APA)
Manekeng, Hermione T.& Mbaveng, Armelle T.& Ntyam Mendo, Samuel A.& Agokeng, Armel-Joseph D.& Kuete, Victor. 2019. Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151187
Modern Language Association (MLA)
Manekeng, Hermione T.…[et al.]. Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1151187
American Medical Association (AMA)
Manekeng, Hermione T.& Mbaveng, Armelle T.& Ntyam Mendo, Samuel A.& Agokeng, Armel-Joseph D.& Kuete, Victor. Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151187