Platelet Rich Plasma for Treatment of Rheumatoid Arthritis: Case Series and Review of Literature
Joint Authors
Badsha, Humeira
Harifi, Ghita
Murrell, William D.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Platelet-rich plasma (PRP) is an autologous blood product with platelets above circulating levels and releases several growth factors after activation.
PRP may help to decrease joint inflammation by modulating synovial cell proliferation and differentiation and inhibition of catabolic pathways in various articular conditions.
Though PRP has shown good efficacy in osteoarthritis and other musculoskeletal conditions such as synovitis, epicondylitis, skeletal muscle injuries, and tendinopathy, there is limited experience for the use of PRP in patients with rheumatoid arthritis.
Precise mechanisms of action of PRP are not known.
We present clinical experience for treatment with PRP (2–4 ml) in four patients with rheumatoid arthritis who had inadequate response and persistent pain and inflammation with intra-articular steroids.
Irrespective of past and ongoing treatments and duration of disease, all patients showed improvement in the visual analog scale and disease activity score of 28 joints at 4 and 8 weeks after injection.
There was an improvement in joint inflammation on ultrasound imaging in some patients.
These effects were sustained for up to 1 year.
No adverse effects were reported in any patient.
PRP may be a safe and useful therapy in patients with rheumatoid arthritis who fail to respond to one or more established treatment options.
American Psychological Association (APA)
Badsha, Humeira& Harifi, Ghita& Murrell, William D.. 2020. Platelet Rich Plasma for Treatment of Rheumatoid Arthritis: Case Series and Review of Literature. Case Reports in Rheumatology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1151188
Modern Language Association (MLA)
Badsha, Humeira…[et al.]. Platelet Rich Plasma for Treatment of Rheumatoid Arthritis: Case Series and Review of Literature. Case Reports in Rheumatology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1151188
American Medical Association (AMA)
Badsha, Humeira& Harifi, Ghita& Murrell, William D.. Platelet Rich Plasma for Treatment of Rheumatoid Arthritis: Case Series and Review of Literature. Case Reports in Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1151188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151188