Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease
Joint Authors
Holtan, Shernan G.
Watson, Allison P.
Brunstein, Claudio G.
Source
Case Reports in Transplantation
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-04
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Ruxolitinib is an oral selective Janus-associated kinase 1 (JAK1) and JAK2 inhibitor that was initially approved by the FDA in 2014 for treatment of myelofibrosis.
In preclinical and retrospective clinical studies, use of ruxolitinib was shown to reduce graft-versus-host-disease (GVHD) in allograft recipients with moderate/severe corticosteroid-dependent or refractory chronic GVHD.
While the exact mechanism for action in GVHD is not yet fully understood, prospective studies are ongoing and some patients are receiving ruxolitinib in the setting of steroid refractory GVHD.
Although ruxolitinib is generally well tolerated, here we describe a case involving a 50-year-old man with acute myeloid leukemia and chronic GVHD who experienced life-threatening hypertriglyceridemia associated with concomitant use of sirolimus and ruxolitinib for GVHD.
This case report highlights the importance of vigilance for severe side effects in novel immunosuppressive drug combinations.
American Psychological Association (APA)
Watson, Allison P.& Brunstein, Claudio G.& Holtan, Shernan G.. 2018. Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease. Case Reports in Transplantation،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1151225
Modern Language Association (MLA)
Watson, Allison P.…[et al.]. Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease. Case Reports in Transplantation No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1151225
American Medical Association (AMA)
Watson, Allison P.& Brunstein, Claudio G.& Holtan, Shernan G.. Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease. Case Reports in Transplantation. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1151225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151225