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Effects of Xuesaitong on the Pharmacokinetics of Losartan: An In Vivo UPLC-MSMS Study
Joint Authors
Nian, Hua
Ma, Weina
Lv, Lei
Guo, Jungang
Meng, Yongjun
Wang, Yinghua
Yang, Xiaoliang
Zhu, Lijun
Zhao, Liang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to examine whether Xuesaitong, a multiherbal formulation for coronary heart disease, alters the pharmacokinetics of losartan.
Adult male Sprague Dawley rats randomly received losartan (10 mg/kg) or losartan plus Xuesaitong (10 mg/kg) through an oral gavage (n = 6).
Multiple blood samples were obtained for up to 36 h to determine the concentrations of losartan and its active metabolite, EXP3174, through ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
Pharmacokinetics were estimated using a noncompartmental model.
The half-life (t1/2) of losartan was decreased by Xuesaitong (4.26 ± 1.51 vs.
6.35 ± 2.10 h; P<0.05).
The apparent volume of distribution (Vd) of losartan was also decreased by the combination of losartan and Xuesaitong (4.41 ± 1.61 vs.
7.20 ± 2.41 mL; P<0.05).
The time to maximum concentration (Tmax) of losartan was increased by Xuesaitong (1.06 ± 1.04 vs.
0.13 ± 0.05 h; P<0.05).
Xuesaitong also decreased the t1/2 of EXP3174 (8.22 ± 1.41 vs.
6.29 ± 1.38 h; P<0.05).
These results suggest that there is a complex interaction between losartan and Xuesaitong.
In addition to enhanced elimination of losartan and EXP3174, Xuesaitong may also decrease the absorption rate and Vd of losartan.
American Psychological Association (APA)
Ma, Weina& Lv, Lei& Guo, Jungang& Meng, Yongjun& Wang, Yinghua& Yang, Xiaoliang…[et al.]. 2019. Effects of Xuesaitong on the Pharmacokinetics of Losartan: An In Vivo UPLC-MSMS Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151248
Modern Language Association (MLA)
Ma, Weina…[et al.]. Effects of Xuesaitong on the Pharmacokinetics of Losartan: An In Vivo UPLC-MSMS Study. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151248
American Medical Association (AMA)
Ma, Weina& Lv, Lei& Guo, Jungang& Meng, Yongjun& Wang, Yinghua& Yang, Xiaoliang…[et al.]. Effects of Xuesaitong on the Pharmacokinetics of Losartan: An In Vivo UPLC-MSMS Study. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151248