Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression
Joint Authors
Yakubu, Idris
Haririan, Abdolreza
Bartlett, Stephen
Sparkes, Tracy
Source
Case Reports in Transplantation
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy.
Despite monozygosity, there is a possibility of discordant protein presentation in identical twins that could trigger alloimmune response and lead to graft injury.
Therefore, the optimal immunosuppression regimen in this patient population is unknown, and the safety of immunosuppression withdrawal remains controversial.
Herein, we describe two patients who underwent successful renal transplantation from monozygotic identical twin donors.
Monozygosity was determined using short tandem repeat (STR) analysis.
All immunosuppression was successfully discontinued at 2 days and 3 weeks, respectively, after transplantation.
Both patients are alive with functioning renal grafts at 1 year and 5 years after transplant, respectively.
These two cases suggest that immunosuppression can be withdrawn safely and rapidly in select monozygous identical twin renal transplant recipients.
American Psychological Association (APA)
Yakubu, Idris& Haririan, Abdolreza& Bartlett, Stephen& Sparkes, Tracy. 2018. Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression. Case Reports in Transplantation،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1151266
Modern Language Association (MLA)
Yakubu, Idris…[et al.]. Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression. Case Reports in Transplantation No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1151266
American Medical Association (AMA)
Yakubu, Idris& Haririan, Abdolreza& Bartlett, Stephen& Sparkes, Tracy. Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression. Case Reports in Transplantation. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1151266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151266